Yes, a famous line from Dumb and Dumber, but also, this phrase could be used to describe the noise Big E was making at dinner.
He was taking his plastic fork and scraping it on the underside of the glass kitchen table. The noise he was producing was comparable with running your nails down a chalkboard.
Little E thought it was funny, so of course Big E continued. He had a captive audience.
And I was about to jump out of my skin.